学术简历

邢秀梅，91吃瓜 卫生毒理系副教授，博士生导师。91吃瓜 卫生毒理学博士，美国马里兰大学药学院博士后。长期致力于职业与环境有害因素的毒性作用与机制研究。主持国家自然科学基金面上2项、青年项目1项。在国内外期刊上参与发表论文30余篇，以第一、通讯（含共同）作者在Environment International、Environmental Pollution、Archives of Toxicology、Aquatic Toxicology、Toxicology and Applied Pharmacology等杂志发表SCI论著。获得科研和教学相关奖励10余项、国家发明专利3项，参编专著5部。

 

主持项目

  1. 国家自然科学基金面上项目，烟酰胺单核苷酸对低浓度苯暴露致血液毒性的干预作用，82473670，研究期限2025.01-2028.12，主持
  2. 国家自然科学基金面上项目，脂肪组织对苯的ADME及其血液毒性的影响和机制研究，81973076，研究期限2020.01-2023.12，主持
  3. 国家自然科学基金青年项目，组蛋白修饰介导职业暴露多环芳烃早期损伤效应机制研究，81402715，研究期限2015.01-2017.12主持
  4. 高校基本科研业务费91吃瓜 青年教师培育项目（研究期限:2014-2017）
  5. 环境污染与疾病监控教育部重点实验室（贵州医科大学）开放项目（2018-2020）
  6. 91吃瓜 实验室开放基金项目（指导老师，2016-2017）

参与项目

作为主要成员参与国家级项目10余项

 

近年来发表的主要期刊论文（#第一作者，* 通讯作者）

  • Lv Y#, Li Z, Chen Y, Qin F, Liao Q, Zhang Z, Deng Q, Liu Q, Long Z, Wang Q, Chen W, Xiao Y, Xing X*. miR-451a and miR-486-5p: biomarkers for benzene-induced hematotoxicity. Arch Toxicol, 2025 Feb; 99(2): 717-728.

  • Lan X#, Huang H#, Liu J#, Zhao J, Li G, Zuo M, Xing X*, Ren X*. Compromised very-low density lipoprotein induced polyunsaturated triglyceride accumulation in N-nitrosodiethylamine-induced hepatic steatosis. Food Chem Toxicol. 2024 Apr;186:114519. 

  • Yang R#, Zhang J#, Xing X#, Zhong S, Li W, Wen L, Zhang Y, Zhou H, Chen S, Chen W, Xiao Y, Chen L*. The involvement of nicotinate and nicotinamide metabolism pathway in attenuating benzene-induced mouse hematotoxicity. Ecotoxicol Environ Saf. 2024 Dec;288:117388. 

  • Lizhu Ye# , Xinhang Jiang#, Liping Chen, Shen Chen, Huiyao Li , Rui Du, Wei You, Jing Peng, Ping Guo, Rui Zhang, Hongyao Yu, Guanghui Dong, Daochuan Li, Xue Li, Wen Chen , Xiumei Xing*, Yongmei Xiao*. Moderate body lipid accumulation in mice attenuated benzene-induced hematotoxicity via acceleration of benzene metabolism and clearance. Environ Int. 2023 Aug; 178: 108113.     

  • Yan Zhang #, Yan Liu, Zongxin Li, Xin Liu, Qingfei Chen, Jingyao Qin, Qilong Liao, Rui Du, Qifei Deng, Yongmei Xiao, Xiumei Xing*. Effects of coexposure to noise and mixture of toluene, ethylbenzene, xylene, and styrene (TEXS) on hearing loss in petrochemical workers of southern China. Environ Sci Pollut Res. 2023 Mar;30(11):31620-31630.

  • Ying Cui#, Ziying Mo#, Penglei Ji, Jingyi Zhong, Zongxin Li, Daochuan Li, Lina Qin, Qilong Liao, Zhini He, Wei Guo, Liping Chen, Qing Wang, Guanghui Dong, Wen Chen, Yongmei Xiao, Xiumei Xing*. Benzene Exposure Leads to Lipodystrophy and Alters Endocrine Activity In Vivo and In Vitro. Front Endocrinol (Lausanne).2022,13:937281.   

  • Zhengbao Zhang#, Xiumei Xing#, Shuyun Jiang, Chunfang Qiu, Ziying Mo, Shen Chen, Liping Chen, Qing Wang, Yongmei Xiao, Guanghui Dong, Yuxin Zheng, Wen Chen, Daochuan Li*. Global H3K79 di-methylation mediates DNA damage response to PAH exposure in Chinese coke oven workers. Environ Pollut. 2021 Jan 1;268(Pt B):115956.  
  • Xiumei Xing#, Zhini He#, Ziwei Wang, Ziying Mo, Liping Chen, Boyi Yang, Zhengbao Zhang, Shen Chen, Lizhu Ye, Rui Zhang, Yuxin Zheng, Wen Chen, Daochuan Li*. Association between H3K36me3 modification and methylation of LINE-1 and MGMT in peripheral blood lymphocytes of PAH-exposed workers. Toxicol Res (Camb), 2020, 9(5):661-668.    
  • Xiumei Xing#, Liwen Hu#, Yuming Guo#, Michael S. Bloom, Shanshan Li, Gongbo Chen, Steve Hung Lam Yim, Namratha Gurram, Mo Yang, Xiang Xiao, Shuli Xu, Qi Wei, Hongyao Yu, Boyi Yang, Xiaowen Zeng, Wen Chen, Qiang Hu*, Guanghui Dong*. Interactions between ambient air pollution and obesity on lung function in children: The Seven Northeastern Chinese Cities (SNEC) Study. Science of the Total Environment, 2020, 699:134397.     
  • Zhini He#, Rui Zhang#, Shen Chen, Liping Chen, Huiyao Li, Lizhu Ye, Qiong Li,  Ziwei Wang, Qing Wang, Huawei Duan, Yong Niu, Yongmei Xiao, Guanghui Dong, Daochuan Li, Dianke Yu, Yuxin Zheng, Xiumei Xing*, Wen Chen. FLT1 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation. Environ Pollut. 2019, 252 (Pt A):607-615. 
  • Xiumei Xing#, Jianmeng Kang, Jiahuang Qiu, Xiali Zhong, Xiongjie Shi, Bingsheng Zhou, Yanhong Wei*.Waterborne exposure to low concentrations of BDE-47 impedes early vascular development in zebrafish embryos/larvae. Aquat Toxicol. 2018, 203:19-27. 
  • Jie Li#, Xiumei Xing#, Xinjie Zhang#, Boxuan Liang , Zhini He, Chen Gao,Shan Wang , Fangping Wang, Haiyan Zhang, Shan Zeng , Junling Fan, Liping Chen, Zhengbao Zhang, Bo Zhang , Caixia Liu, Qing Wang, Weiwei Lin, Guanghui Dong, Huanwen Tang, Wen Chen, Yongmei Xiao, Daochuan Li*, Enhanced H3K4me3 modifications are involved in the transactivation of DNA damage responsive genes in workers exposed to low-level benzene, Environ Pollut. 2018, 234:127-135. 
  • Chen Gao#, Xiumei Xing#, Zhini He, Shen Chen, Shan Wang, Qingye Li, Ping Guo, Haiyan Zhang, Huiyao Li, Liping Chen, Qing Wang, Jian Zhao, Yongmei Xiao, Wen Chen*, Daochuan Li*, Hypermethylation of PGCP gene is associated with human bronchial epithelial cells immortalization, Gene, 2018, 642: 505-512.   
  • 莫子颖#，肖勇梅，邢秀梅*. 职业接触甲苯暴露生物标志物研究进展.职业与健康杂志, 2021，37(6) :855-864.

发明专利

  参与获得国家发明专利2项：ZL 2015 1 0450018.6；ZL 2010 1 0255674.8

慕课建设

  课程名称： 《毒理学之历史案例分析》    课程负责人

  慕课学习平台：学堂在线、粤港澳大湾区高校在线开放课程联盟、91吃瓜 在线教学平台

 

学术专著

  1. 《现代毒理学》，参编第三十五章模式生物及其在毒理学中的应用；  ISBN：978-7-117-26011-4/R.26012
  2. 《机制毒理学》，参编第二章机制毒理学研究的实验模型；ISBN：978-7-03-066806-6 

 

获奖情况

  1. 中国毒理学会第十次全国毒理学大会报告    优秀论文
  2. 91吃瓜 2023年教师教学竞赛  一等奖 
  3. 91吃瓜 2024年优秀硕士毕业生（指导老师）
  4. 中华预防医学会科技奖（参与）   二等奖
  5. 中国健康科普大赛（广东省赛区） 三等奖（指导老师）
  6. 91吃瓜 2019年度优秀个人 
  7. 第十届中国科协年会优秀论文（参与）   二等奖
  8. 湖南省第十三届自然科学优秀学术论文（参与） 三等奖

 

招生类别与专业

  卫生毒理学 硕士/博士

  公共卫生硕士（MPH）

 

联系方式

  电子邮箱：[email protected]

  地址：广州市中山二路74号大院 91吃瓜 （邮编510080）